Are you wondering about STEM project ideas? Do you want to get noticed in the science discipline? Then you should check out the Regeneron International Science and Engineering Fair (ISEF) competition. This competition was founded by the Society for Science in partnership with Regeneron Pharmaceuticals in 1950. It is one of the most prestigious science fairs for high school students, and one of the largest as well: students from more than 75 countries can participate in this competition.
ISEF covers a wide range of STEM subjects, and students can submit projects in one of the following:
The most recent rules and guidelines can be found on the ISEF website. However, it is worth highlighting the following for a quick eligibility check:
The winners of the 2025 competition have already been announced. First place went to Matteo Paz, 18, of Pasadena, for a space science project on ‘undiscovered brightness-variable objects’. The ceremony and the other finalists can be watched here.
However, if you intend to compete in 2026, the first step is to find an ISEF-affiliated fair near you. Fairs exist in nearly every US state and in over 70 countries. ISEF is also holding an in-depth event week in Phoenix, Arizona, from May 9-1,5 2026.
Grand Awards are awarded for each subject category:
If you complete your project as a team, the award should be split equally among team members.
Many past ISEF winners presented interdisciplinary research projects combining two disciplines, e.g., biology and technology or data science. To make your project stand out, use laboratory equipment and present your data analysis in a structured way.
Some of these projects need chemical analysis tools such as spectrometers and as well as a rigorous understanding of research ethics, especially if they involve handling bioactive compounds. Moreover, it is worth noting that projects that combine traditional chemistry with modern sustainability concerns tend to resonate well with both judges and the broader scientific community.
To increase your chances of success, use Python, R, or MATLAB, employ data visualisation tools, AI frameworks, and statistical software. From our experience mentoring students in this category, we have found that projects combining cutting-edge technology with humanitarian applications consistently perform well in competition. Analysing past projects, it is also clear that judges value projects that showcase real-world applications.
These projects may need engineering simulation tools, CAD software, and prototyping equipment. Physics and Astronomy projects that win frequently collaborate with national and or university observatories.
Our advice would be to focus on projects that can demonstrate both theoretical understanding and practical implementation, as this combination tends to impress judges across multiple evaluation criteria.
Environmental innovation is a powerful ISEF project category. Environmental projects have particular relevance in today's climate-conscious world, and judges often appreciate research that addresses pressing global challenges with innovative scientific approaches.
These projects integrate bioinformatics tools, machine learning, and genetic analysis software. Students are encouraged to work with university professors for guidance and lab access.
In our experience, medical research projects require particularly careful attention to ethical considerations and safety protocols, but they often yield highly impactful results that capture judges' attention.
A strong ISEF project relies on:
Judges look for rigorous application of the scientific method, with well-documented procedures and replicable results. We have observed that projects with the most methodical approach to experimental design tend to perform better, regardless of the specific research topic.
Understanding statistical and data analysis is critical. Projects must discuss findings through:
This guarantees scientific credibility and can endure examination throughout the peer review process. In our experience working with student researchers, we have found that those who invest time in learning proper statistical analysis techniques early in their project development cycle tend to produce more compelling and defensible results.
ISEF requires adherence to:
Failure to comply can even result in disqualification. We would strongly advise students to familiarise themselves with these requirements at the project planning stage rather than attempting to address them at a later stage.
A typical ISEF-worthy project spans 6–12 months, aligned with the academic school year.
Recommended timeline:
From our experience mentoring students through this process, we believe that adhering to this timeline is crucial for producing quality research without overwhelming stress in the final months.
The journey to ISEF success requires not only innovative project ideas but also professional guidance, rigorous methodology, and access to cutting-edge research techniques.
For students seeking to maximize their potential in science fair competitions, comprehensive mentorship can make the difference between participation and excellence. At Indigo Research, experienced researchers and former ISEF winners provide personalized guidance to help students develop award-winning projects from conception to presentation. Whether you need assistance with experimental design, data analysis, or presentation skills, professional mentorship ensures that your innovative ideas receive the support they deserve to compete at the highest levels of international science competition.
Gain necessary skills to win ISEF by doing research in your high school. Choose any topics that you're passionate and learn from professional mentors from top universities!
.png)
Gain necessary skills to win ISEF by doing research in your high school. Choose any topics that you're passionate and learn from professional mentors from top universities!
